Endonuclease IV,E.coli

Product name:Endonuclease IV,E.coli

Product Applications
DNA repair research.
Antitumor drug evaluation.
Endonuclease IV, cloned from the E.coli nfo gene, is a metalloenzyme that functions in vivo to repair free-radical damage in DNA.1 The enzyme has Class II abasic endonuclease activity, which has utility in many areas of DNA damage and repair research.1 The enzyme can also act as an 3? diesterase. Endonuclease IV is useful in the study of the effects of antitumor drugs such as bleomycin on nucleic acids in vivo.2.

Unit Definition: One unit of Endonuclease IV will relax 1 ?g of partially depurinated, covalently closed supercoiled plasmid DNA in 30 minutes at 37??C under standard assay conditions.