Hyaluronidase

Product Name:Hyaluronidase 
 
CAS:488712-31-8
 
Molecular Formula:C2455H3775N617O704S21 
 
Molecular Weight:53870.9 g/mol

Product Description
By catalyzing the hydrolysis of hyaluronic acid, a major constituent of the interstitial barrier, hyaluronidase lowers the viscosity of hyaluronic acid, thereby increasing tissue permeability. It is, therefore, used in medicine in conjunction with other drugs in order to speed their dispersion and delivery. The most common application is in ophthalmic surgery, in which it is used in combination with local anesthetics. It also increases the absorption rate of parenteral fluids given by hypodermoclysis, and is an adjunct in subcutaneous urography for improving resorption of radiopaque agents. Hyalurodinase is also used for extravasation of hyperosmolar solutions. Usually a 0.2 ml of the drug is injected around the area of extravasation. A total of 1 ml is used.

Role in cancer metastasis
Hyaluronidases may play a role in cancer metastasis. It has been hypothesized that by helping degrade the extracellular matrix (ECM) surrounding the tumor, hyaluronidases help the cancer cell escape from the primary tumor mass. Hyaluronidases are also thought play a role in the process of angiogenesis although most hyaluronidase preparations are contaminated with large amounts of angiogeneic growth factors. As previously mentioned, there are six hyaluronidase genes in the human genome of which four can express active hyaluronidases.