Phosphoglucomutase

Product Name:Phosphoglucomutase

Product Description:Phosphoglucomutase (EC 5.4.2.2) is an enzyme that transfers a phosphate group on a glucose monomer from the 1' to the 6' position in the forward direction or the 6' to the 1' position in the reverse direction. To be specific, it facilitates the interconversion of glucose 1-phosphate and glucose 6-phosphate.

Product Function:The enzyme phosphoglucomutase phosphorylates the 6-carbon, while subsequently dephosphorylating the 1-carbon. The result is glucose-6-phosphate, which can now travel down the glycolysis or pentose phosphate pathway. Phosphoglucomutase also acts in the opposite fashion when a large concentration of glucose-6-phosphate is present. In this case, it is the 1-carbon that is phosphorylated and the 6-carbon that is dephosphorylated. The resulting glucose-1-phosphate is then changed into UDP-glucose in a number of intermediate steps. If activated by insulin, glycogen synthase will proceed to clip the glucose from the UDP-glucose complex and on to the glycogen molecule.