Celastrol

Product Name:Celastrol
CAS No.: 34157-83-0
Molecular Formula: C29H38O4
Molecular Weight: 450.61
Botanical Source: Tripterygium wilfordii
Purity: 98% HPLC
Appearance: Red powder
Package: 25 kg/drum
Storage: Stored in cool & dry places, protected from direct sunlight and heat.
Description:
Celastrol is extracted from Tripterygium wilfordii.In low nanomolar concentrations celastrol was found to suppress the production by human monocytes and macrophages of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Celastrol also decreased the induced expression of class II MHC molecules by microglia. In macrophage lineage cells and endothelial cells celastrol decreased induced but not constitutive NO production.The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD.