7-hydroxy-mitragynine

Product name : 7-hydroxy-mitragynine

CAS : 174418-82-7

Molecular formula : C₂₃H₃₀N₂O₅

Product description :
7-Hydroxymitragynine, an indole, is an active alkaloid in the plant Mitragyna speciosa, commonly known as Kratom. It has opioid agonistic activity."The potency, calculated using pD  values, was 30- and 17-fold higher than that of mitragynine and morphine, respectively.Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of M. speciosa is mostly based on the activity of 7-hydroxymitragynine."

7-Hydroxymitragynine is orally active in animals as an analgesic, and produces normal opioid side effects including constipation[4] development of tolerance and withdrawal syndrome upon abstinence. The O-acetyl ester, 7-acetoxymitragynine has also been reported and found to be an active μ-opioid agonist.