Aliskiren

Product Name : Aliskiren

CAS : 173334-57-1

Mol. Formula : C₃₀H₅₃N₃O₆

Mol. mass : 551.758

Product Description : Aliskiren (INN) is the first in a class of drugs called direct renin inhibitor. Its current licensed indication is primary (previously essential) hypertension.

Use :
Aliskiren is a minor substrate of CYP3A4 and, more important, P-glycoprotein:
1.duces furosemide blood concentration.
2.orvastatin may increase blood concentration, however no dose adjustment needed.
3.ssible interaction with cyclosporin ( the concomitant use of cyclosporin and aliskiren is contraindicated).
4.ution should be exercised when aliskiren is administered with ketoconazole or other moderate P-gp inhibitors (itraconazole, clarithromycin, telithromycin, erythromycin, amiodarone).