(-)-Arctigenin

Product name:(-)-Arctigenin
CAS Number: 7770-78-7
Purity: 98%
Molecular Weight: 372.41
Molecular Formula: C21H24O6
Specification: 20mg
Appearance: White to off-white solid.
Physical State: Solid
Solubility: Soluble in DMSO (34 mg/ml), water (sparingly), and ethanol (25 mM).
Storage:Store at -20° C
Melting Point: 219.94 °C (Predicted)
Boiling Point: 567.00 °C at 760 mmHg (Predicted)
Density: 1.23 g/cm3 (Predicted)
Application: A dibenzyl butyrolactone lignan agent with anti-inflammatory and antioxidant properties
Description:
Arctigenin is a dibenzyl butyrolactone lignan agent with anti-inflammatory and antioxidant properties. Studies describe Arctigenin to potently block TNF- α production and NO secretion. MAP kinase studies show that Arctigenin effectively inhibits the activity of MAP kinases and AP-1 activation through vigorous inhibition of MKK. Additional studies report that Arctigenin acts as a potent inhibitor of PAC-1 activity. Arctigenin has also been shown to bind to kainic acid receptors and protect neurons from neurodegeneration induced by glutamate, and inhibit HIV-1 integrase. Furthermore, this compound acts as an inhibitor of IκB phosphorylation. Arctigenin is an inhibitor of MEK-1 and Topo II.