BMS 708163

Product name  : BMS 708163

CAS :1146699-66-2

Molecular formula : C₂₀H₁₇ClF₄N₄O₄S

Molecular weight : 520.88

Product description :
BMS-708163 is a potent and selective γ-secretase inhibitor (GSI) (IC50 =0.3 nM).
Phase I clinical trial studies showed that in humans, this agent decreased CSF Aβ40 and Aβ42 approximately 30 percent following daily dose of 100 mg after 28 days and by 60 percent at daily dose of 150 mg. [2] BMS-708163 has an IC50 for APP cleavage of 0.3 nM, significantly more potent than GSI-953, another selective GSI (15 nM). [2] BMS-708163, is 190-fold more selective for APP than Notch, having an IC50 of 58 nM for Notch.