GDC-0449(vismodegib)

Product name : GDC-0449(vismodegib)

CAS : 879085-55-9

Molecular formula : C₁₉H₁₄Cl₂N₂O₃S

Molecular weight : 421.3

Product description :
GDC-0449 is a more potent and specific synthetic oral SMO(signaling transducer Smoothened)inhibitor，with 0.003μM of Gli-luc (Gli-luciferase assay) IC50,which inhibits the growth of primary pancreatic xenografts without non-specifically inhibiting pancreatic cell proliferation in vitro and has recently entered the clinic.
GDC-0449 (HhAntag691), a promising anticancer drug that targets the tumor- promoting hedgehog (Hh) pathway，also inhibits ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. The IC50 values of GDC-0449 for inhibition of ABCG2 and Pgp were ?1.4 and ?3.0μM, respectively.
GDC-0449 (HhAntag691), has been used to treat medulloblastoma in animal models and has recently entered clinical trials for a variety of solid tumors.