Geldanamycin

Product name:Geldanamycin
CAS: 30562-34-6
Molecular Formula: C29H40N2O9
Molecular weight:560.6359
Appearance:white powder
Purity:99%
Storage:Avoid exposure to sunlight,Keep dry
Product description :Geldanamycin is a benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells.