N-b-D-glucopyranosyl-5-ASA

Product name : N-b-D-glucopyranosyl-5-ASA

Product Description :
1. A new unstable metabolite of 5-aminosalicylic acid (5-ASA) was found in plasma from healthy volunteers dosed with 5-ASAi.v.
2. The metabolite was prepared by incubation of 5-ASA with rat liver homogenate, and isolated using preparative?h.p.l.c.
3. The metabolite was identified as N-β-D-glucopyranosyl-5-aminosalicylic acid by n.m.r. spectroscopy and by FAB mass spectrometry.
4. N-β-D-Glucopyranosyl-5-ASA was formed non-enzymically from 5-ASA and glucose in phosphate buffer pH7.4, and was unstable under weakly acidic conditions, decomposition increasing with temperature, i.e. decomposition was complete after 30?min at pH 5.0 and 23°C.