Pixantrone

Product name : Pixantrone

CAS : 144510-96-3

Molecular formula : C₁₇H₁₉N₅O₂

Product description :
Pixantrone (6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione; rINN) is an experimental antineoplastic drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent.The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials.Anthracyclines are important chemotherapy agents; however, their use is associated with irreversible and cumulative heart damage. Investigators have attempted to design related drugs which maintain the biological activity, but do not possess the cardiotoxicity of the anthracyclines. Pixantrone was developed to reduce heart damage related to treatment while retaining efficacy.