Terrequinone A

Product name : Terrequinone A

Molecular Formula : C₃₂H₃₀N₂O₃

Molecular Weight : 490.592

Product Description :
Terrequinone A represents a unique member of a family of bisindolylbenzoquinones commonly known as asterriquinones. Since the initial discovery of cochliodinol, an antifungal agent2 from various Chaetomium species3, several new asterriquinones, including asterriquinone CT5 and asterriquinone B1, have been isolated from various species of Aspergillus terreus4, 5, Humicola and Botryotrichum6. All share a common dihydroxybenzoquinone core and vary mainly in the pattern of prenylation on the indole substituents. Like terrequinone A, most isolated asterriquinones are cytotoxic compounds that have been shown to intercalate genomic DNA, thus predisposing tumor cells to apoptosis7. Structure-activity studies on the asterriquinones have demonstrated that the hydroxyls of the symmetric dihydroxybenzoquinone core are important for antitumorigenic activity8. However, terrequinone A is the only asterriquinone asymmetrical in its quinone core, bearing an isopentenyl moiety in place of one of the hydroxyls.